Publications and Presentations

BOOK CHAPTER

Belas, F.J. and Blair, I.A. (2002) Mass spectrometry in pharmaceutical analysis In:  Handbook of Pharmaceutical Analysis, Edited by Ohannesian, Lena.A., and Streeter, Anthony J. Marcel Dekker, Inc. pg. 151-185.

PUBLICATIONS

  • Mullen, J.H., Shugert, R.L., Ponsler, G.D., Li, Q., Sundaram, B., Coales, H.L., Yakupkovic, J.E., LeLacheur, R.M., Wheeler, W.J., Belas, F.J., and Sauer, J.M.  Simultaneous Quantification of Atomoxetine and its Primary Oxidative Metabolites in Human Plasma and Urine using Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS). 2005. Journal of Pharmaceutical and Biomedical Analysis 38:720-733.
  • Belas, F.J. and Blair, I.A. Mass spectrometry in pharmaceutical analysis.  J. Liposome Res., 11(4):309-342 (2001).
  • Zhang J.Y., Fast, D.M., Schoenhard, G.L., Arora, V.K., Belas, F.J., and Blair, I.A.  Quantitative determination of SC-68328 in dog plasma using flow injection and tandem mass spectrometry.  J. Mass Spectrom., 35:354-360 (2000).
  • Kim, Richard B., Wandel, Christoph, Leake, Brenda, Cvetkovic, Mirjana, Fromm, Martin F., Dempsey, Peter J., Roden, Mark M., Belas, Frank, Chaudhary, Ajai, K., Roden, Dan M., Wood, Alastair, J.J., and Wilkinson, Grant R.  Interrelationships between substrates and inhibitors of human CYP3A and P-glycoprotein.  Pharm. Res., 16:408-414 (1999).
  • Mueller, Michael, Belas, Frank J., Blair, Ian A., and Guengerich, F. Peter.  Analysis of 1,N2-e-deoxyguanosine and N2-(2-oxoethyl)guanine (5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine) in DNA treated with 2-chlorooxirane by high performance liquid chromatography/tandem mass spectrometry. Chem. Res. and Tox. 10(2):  242-247 (1997).
  • Lang, Chim C., Stein, Michael, Nelson, Richard A., He, Huai B., Belas, Frank J., Blair, Ian A., Wood, Margaret, and Wood, Alastair J.J. Sympathoinhibitory response to clonidine is blunted in patients with heart failure.  Hypertension, 30:  392-397 (1997).
  • Lang, Chim C., Stein, Michael, He, Huai B., Belas, Frank J., Blair, Ian A., Wood, Margaret, and Wood, Alastair J.J.  Blunted blood pressure response to central sympathioinhibitionin normotensive blacks. Hypertension 30:  157-162 (1997).   
  • Srinivas, N.R, Barr, W.H., Shyu, W.C., Mohandoss, E., Chow, S., Staggers, J., Balan, G., Belas, F.J., Blair, I.A., and Barbhaiya, R.H.  Bioequivalence of two tablet formulations of nadolol using single and multiple dose data:  Assessment using stereospecific and non‑stereospecific assays.  J. Pharmaceutical Sciences 85: 299-303 (1996).
  • Mueller M., Belas, F.J., Ueno, H, and Guengerich, F.P.  Development of a mass spectrometric assay for 5,6,7,9‑tetrahydro7‑hydroxy‑9‑oximidazo [1,2‑a]purine in DNA modified by 2‑chloro‑oxirane.  Advances in Experimental Medicine and Biology, 387:  31-36 (1996)
  • Belas, F.J., Phillips, M.A., Srinivas, N.R., Barbhaiya, R.H., and Blair, I.A.  Simultaneous determination of nadolol enantiomers in human plasma by high-performance liquid chromatography using fluorescence detection.  Biomedical Chromatography, 9: 140-145 (1995).
  • Belas, F.J., Francis, J.C., and Poirrier, M.A.  Significance of small organic chelators in laboratory cultures of Ephydatia fluviatilis (Poriferia:  Spongillidae).  Trans. Am. Microsc. Soc., 111(3):  169‑179 (1992).
  • Belas, F.J., Francis, J.C., and Poirrier, M.A.  Effects of calcium, magnesium, and sodium on growth of Ephydatia fluviatilis (Poriferia:  Spongillidae).  Trans. Am. Microsc. Soc., 108(2):  139‑151 (1989).

PUBLISHED ABSTRACTS / ORAL PRESENTATIONS

Mullen, John H., Shugert, Richard L., Ponsler, George D., Li, Qimin, Belas, Frank J., and Sauer, John-Michael.  Quantification of Tomoxetine and its N-Desmethyl metabolite in human plasma and multiple animal species plasma using Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS).  ISSX Proceedings: 10th North American ISSX Meeting, Volume 32, pg. 173, October 24-28, 2000, Indianapolis, Indiana.

Knotts, K., Satonin, D., Ruterbories, K., Ackermann B., Shugert, R., Czeskis, B., Li, Q., He, M., and Belas, F.  Development of a LC/MS/MS assay for the quantification of LY326869 and its dehydrogenated metabolite in human plasma. Proceedings:  The 48th ASMS Conference on Mass Spectrometry and Allied Topics, pg. 64; June 11-15, 2000, Long Beach, California.

Belas, Frank J.  Building a bioanalytical organization in a GLP environment: scientific, logistical, and regulatory considerations.  Lecture presented to the Department of Pharmaceutical Sciences, Eli Lilly and Company, Indianapolis, Indiana, July 23, 1999.

Perkins, John R., Brewer, Edward J., Vitale, Karla J., Mann, Matthew C., Humphries, David, Li, Qimin, Garner, Carlos O., Belas, Frank J., and Henion, Jack.  Determination of LY333531 and its desmethyl metabolite in plasma from multiple species by API LC/MS/MS.  Proceedings:  The 47th ASMS Conference on Mass Spectrometry and Allied Topics, pg. 1061; June 13-17, 1999, Dallas, Texas.

Satonin, D.K., Aldridge, T.E., Farid, N.A., Ruterbories, K.J., Rowe, J., Ackermann, B.L., Belas, F.J.  Analysis of LY315920 in human plasma using ESI LC/MS/MS.  1999.  AAPS PharmSci Supplement, 1999 AAPS Annual Meetings Abstracts Online, Volume 1/Issue 4; abstract number 2163, pg. 472.

Kim, R.B., Leake, B., Cvetkovic, M., Wandel, C., Roden, M.M., Fromm, M.F., Chaudhary, A.K., Belas, F., Roden, D.M., Wood, A.J.J., Wilkinson, G.R.  Transport of P450 (CYP) drug substrates by P-glycoprotein.  Clin. Pharmacol. Ther., 63: 206, 1998. 

Belas, Frank J., Delaporte, Enock, White, Linda, and Wilkinson, Grant.  Method Development for measurement of coumarin and its 7-hydroxy metabolite as a CYP2A6 in vivoprobe in humans using LC/MS/MS.  Proceedings:  The 45th ASMS Conference on Mass Spectrometry and Allied Topics, pg. 705; June 1-5, 1997, Palm Springs, California.

Arora, Vinod K., Belas, Frank J., Chaudhary, Ajai K., Mayol, Robert F., Gaver, Robert C., Gale, Jane P., and Blair, Ian A.  Analysis of in vivo biotransformation products of JM216, an orally active platinum anticancer drug, by LC/MS/MS.  Proceedings: The 45th ASMS Conference on Mass Spectrometry and Allied Topics, pg. 1076; June 1-5, 1997, Palm Springs, California.

Lang, C.C., Stein, M.C., Belas, F.J., Blair, I.A., Wood, M. and Wood, A.J.J.  Sympathetic activation in the elderly:  is it due to impaired alpha-adrenergic feedback sympathoinhibition? Clin. Pharmacol. Ther., 61, 229.  1997.

Garner, Carlos O., Belas, Frank J., and Blair, I.A.  Characterization of cyclooxygenase derived metabolism of 8,9 epoxyeicosatrienoic acid using LC ESI/MS and LC ESI/MS/MS.  Proceedings:  The 44th ASMS Conference on Mass Spectrometry and Allied Topics, pg. 241; May 12-16, 1996, Portland, Oregon.

Arora, Vinod, Belas, Frank, Zhang, Ji, Fast, Doug, Schoenhard, Grant, and Blair, Ian.  The analysis of SOD mimetic SC-68328 in dog plasma using flow-injection ESI/MS/MS.  Proceedings:  The 44th ASMS Conference on Mass Spectrometry and Allied Topics, pg. 1320; May 12-16, 1996, Portland, Oregon.

Belas, Frank J., Yeola, Suresh N., Garner, Carlos O., Saleh, Samir A., Chaudhary, Ajai K., Migdalof, Bruce H., and Blair, Ian A.  Determination of 2-amino-5,6-dichloro-3,4-dihydroquinazoline, a major urinary metabolite of anagrelide, by liquid chromatography/tandem mass spectrometry (LC/MS/MS).  Proceedings:  The 43rd ASMS Conference on Mass Spectrometry and Allied Topics pg. 555, May 21‑26, 1995, Atlanta, Georgia.

Goldthwaite, Jr., Charles A., Belas, Frank J., Phillips, Mark A., Anthony, Lowell, and Blair, Ian A. Development of a sensitive LC/ESI/MS/MS assay for the antineoplastic agents cyclophosphamide and ifosfamide.  Proceedings:  The 43rd ASMS Conference on Mass Spectrometry and Allied Topics pg. 554, May 21‑26, 1995, Atlanta, Georgia.

Garner, Carlos O., Belas, Frank J., and Blair, Ian A.  Analysis of cytochrome P-450 metabolites of arachidonic acid using LC MS/MS.  Proceedings:  The 43rd ASMS Conference on Mass Spectrometry and Allied Topics pg. 536, May 21‑26, 1995, Atlanta, Georgia.

Mueller, Michael M., Belas, Frank J., Blair, I. A., and Guengerich, F. Peter.  Assays of the vinyl chloride epoxide products 1,N2‑ethenoguanine and 5,6,7,9‑tetrahydro‑7‑hydroxy‑9‑oximidazo [1,2‑a]purine by mass spectrometry.  ISSX Proceedings:  Fourth International ISSX Meeting, pg. 403, August 27‑31, 1995, Seattle, Washington.

Belas, F.J. and Blair, I.A.  Analytical methods development and good laboratory practices. Presented at the Vanderbilt University Medical Center Bioanalytical Resource Workshop-“Analysis of DNA-Adducts Using Mass Spectrometry”, Nashville, Tennessee, August 14-18, 1995.

Belas, F.J. and Blair, I.A.  Development of a sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay for the antitumor agent 9‑aminocamptothecin.  Presented at the 9‑Aminocamptothecin Investigators Meeting of the American Society of Clinical Oncology, Los Angeles California, May 19, 1995.

Belas, Frank J., Phillips, Mark A., Srinivas, Nuggehally R., Barbhaiya, Rashmi H. and Blair, Ian A. Characterization of nadolol enantiomers in human plasma by HPLC and LSI MS/MS. Proceedings: The 42nd ASMS Conference on Mass Spectrometry and Allied Topics pg. 79, May 29‑June 3, 1994, Chicago, Illinois.

Belas, Frank J., Kamel, Amin, Klunk, Lewis J., Mayol, Robert, and Blair, Ian A.  Enantioselective glucuronidation of the antipsychotic agent 4‑fluorophenyl‑hydroxybutyl‑5‑fluoro‑pyrimidinylpiper-azine (5F‑FHPP) and selected analogs by rat liver UDP‑glucuronosyltransferases (UDPGTs). Proceedings:  The 41st ASMS Conference on Mass Spectrometry and Allied Topics pgs. 333a‑333b, May 31‑June 4, 1993, San Francisco, California.

Belas, F.J., Francis, J.C., and Poirrier, M.A.  Effects of natural chelators on growth of Ephydatia fluviatilis (Poriferia:  Spongillidae) Trans. Am. Microsc. Soc., 108(1):  108‑109.  1989.  Paper presented at the meeting of the American Microscopical Society, San Francisco, California, December 27‑30, 1988.

Belas, F.J., Francis, J.C., and Poirrier, M.A.  Interactions in metabolism of calcium, magnesium, and sodium in the freshwater sponge Ephydatia fluviatilis (Poriferia:  Spongillidae) Trans. Am. Microsc. Soc., 107(1):  104.  1988.  Paper presented at the meeting of the American Microscopical Society, New Orleans, Louisiana, December 27‑30, 1987.

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